Annual review of global liver transplantation research in 2024: technological breakthroughs, precision management and future challenges
10.12464/j.issn.1674-7445.2025099
- VernacularTitle:2024年全球肝移植研究年度盘点——技术突破、精准管理与未来挑战
- Author:
Yong JIANG
1
;
Xiao FENG
1
;
Wei LIU
1
;
Yang YANG
1
Author Information
1. Department of Liver Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangdong Provincial Laboratory of Transplantation Medical Engineering, Guangzhou 510630, China.
- Publication Type:AcademicSummary
- Keywords:
Liver transplantation;
Donor liver source;
Machine perfusion;
Split liver transplantation;
Xenotransplantation;
Liver cancer liver transplantation;
Perioperative management;
Complication prevention and control
- From:
Organ Transplantation
2025;16(3):350-358
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, significant progress has been made in the field of liver transplantation in terms of donor expansion, technological innovation and perioperative management. Machine perfusion technology, through dynamic repair and assessment of donor liver quality, can effectively reduce postoperative complications and increase the utilization rate of marginal donor livers. The optimization of split liver transplantation technology combined with normothermic perfusion further alleviates the shortage of donors, but its promotion is still limited by technical barriers. Xenotransplantation has achieved preclinical breakthroughs in the field of genetically modified pig livers, but ethical and immune barrier issues need to be urgently resolved. In the field of liver cancer liver transplantation, the focus is on neoadjuvant treatment with immune checkpoint inhibitors and the development of recurrence prediction models, which promotes precise treatment. For perioperative management, the optimization of individualized immunosuppressive regimens, artificial liver support, and strategies for the prevention and control of vascular complications has significantly improved patients’ survival rates. Personalized treatment for children, elderly recipients, and recipients with multiple comorbidities provides new ideas for liver transplantation in special populations. In the future, liver transplantation research may focus on the integration of multidisciplinary approaches, individualized treatment and emerging technologies to advance the global liver transplantation cause to new heights.
