Research progress on mechanism of antidepressant action of curcumin
- VernacularTitle:姜黄素抗抑郁作用机制的研究进展
- Author:
Jianping ZHOU
1
;
Yuting XI
2
;
Hao FU
1
;
Ce ZHOU
1
Author Information
1. Dept. of Anorectology，Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China
2. Dept. of Anorectology，Zigong Hospital of Traditional Chinese Medicine，Sichuan Zigong 643010，China
- Publication Type:Journal Article
- Keywords:
curcumin;
depression;
neurotransmitter;
inflammatory response;
oxidative stress;
mechanism
- From:
China Pharmacy
2025;36(9):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
Curcumin is a natural yellow pigment， a natural phenolic antioxidant extracted from the rhizomes of Curcuma longa and Curcumae Rhizoma of the ginger family， with anti-inflammatory， anti-tumor and antioxidant properties. In recent years， it has been found that curcumin also has good antidepressant properties， and it is considered a safe and effective antidepressant potential drug. The mechanism of curcumin’s antidepressant efficacy mainly includes regulating neurotransmitters， modulating the hypothalamic-pituitary-adrenal axis， regulating brain-derived neurotrophic factor， inhibiting neuroinflammation， inhibiting oxidative stress， and regulating gut microbiota， etc.， and there is an overlapping and synergistic therapeutic effect of the above mechanisms. At present， the antidepressant mechanism of curcumin is still not fully understood， and will be combined with multi-omics technology， new formulation technology， and clinical trials to obtain further breakthroughs in the future.
