Research Development of Radiation-Induced Lymphopenia
10.3971/j.issn.1000-8578.2025.24.0998
- VernacularTitle:放射性淋巴细胞减少症相关研究进展
- Author:
Yue WANG
1
;
Hui ZHU
1
Author Information
1. Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400037, China.
- Publication Type:REVIEWS
- Keywords:
Radiation-induced lymphopenia;
Radiotherapy;
Absolute lymphocyte counts
- From:
Cancer Research on Prevention and Treatment
2025;52(4):337-341
- CountryChina
- Language:Chinese
-
Abstract:
When radiotherapy is administered, many patients exhibit a reduction in lymphocyte numbers due to the inherent radio-sensitivity of lymphocytes. In particular, they experience a decrease in CD8+ T cells, which may weaken their mediated antitumor immune response. While radiotherapy activates the immune system, it can also lead to a certain degree of immunosuppression. Current research suggests that the formation mechanism of radiation-induced lymphopenia (RIL) involves multiple factors, including increased radiation exposure to lymphocytes and the application of lymphocytotoxic drugs. The adverse impact of RIL on patients’ clinical outcomes can be mitigated, to some extent, by actively optimizing radiotherapy dosimetric parameters to maximally protect lymphocytes.
