Research progress on low-intensity pulsed ultrasound in promoting osseointegration of dental implants
10.12016/j.issn.2096-1456.202440418
- VernacularTitle:低强度脉冲超声促进牙种植体骨结合的研究进展
- Author:
ZHANG Xinyu
1
;
QU Fang
1
;
XU Chun
1
Author Information
1. Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology
- Publication Type:Review
- Keywords:
low-intensity pulsed ultrasound (LIPUS);
dental implants;
osseointegration;
bone marrow stromal stem cells;
osteogenesis;
osteoporosis;
α-calcitonin gene-related peptide;
mitogen-activated protein kinase
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(5):417-424
- CountryChina
- Language:Chinese
-
Abstract:
How to effectively promote osseointegration of dental implants remains a pressing clinical challenge. Low-intensity pulsed ultrasound (LIPUS) has demonstrated remarkable efficacy in accelerating the healing of various bodily tissues, including bone tissue. In recent years, there has been extensive research on its application in promoting osseointegration in the field of dental implantology. Animal studies have shown that LIPUS exhibits significant potential in facilitating osseointegration of dental implants. In vitro experiments have further revealed that LIPUS can enhance the expression of key osteogenic factors, extracellular matrix mineralization, and induce local neurons to secrete αCGRP. Through the regulation of signaling pathways such as bone morphogenetic protein/Smad (Bmp/Smad), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase/protein kinase B (PI3k/Akt), LIPUS promotes the proliferation, migration, and osteogenic differentiation of osteogenic-related cells, thereby enhancing osseointegration of dental implants. Additionally, clinical studies have shown that bone mass increases around the implants after LIPUS treatment, with more pronounced growth observed on the buccal bone plate than on the palatal side. Furthermore, there is a lack of research that systematically summarizes the clinical evidence, in vitro and in vivo studies, and mechanisms of action regarding the role of LIPUS in promoting osseointegration of implants. Therefore, the aim of this study is to discuss the mechanisms of effect of LIPUS on osseointegration of implants, with the goal of further enhancing the outcome of implant-supported prosthodontic treatment.
- Full text:2025050908490915584低强度脉冲超声促进牙种植体骨结合的研究进展.pdf
