Toxic Components， Toxicity Mechanisms， Toxicity Attenuation Measures， and Evaluation Methods of Renal Injury-inducing Chinese Medicine
10.13422/j.cnki.syfjx.20242129
- VernacularTitle:肾损伤中药成分、机制、减毒措施及评价方法
- Author:
Xin HUANG
1
;
Lujin ZHANG
1
;
Mingsan MIAO
1
;
Can WANG
1
Author Information
1. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao， Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Review
- Keywords:
renal injury-inducing Chinese medicine;
toxic components;
occurrence mechanism;
toxicity attenuation measures;
evaluation method
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(11):295-304
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveWe reviewed the existing experimental studies about renal injury-inducing Chinese medicine and systematically analyzed the toxicity mechanisms， toxic components， toxicity attenuation measures， and modern evaluation methods of renal injury-inducing Chinese medicine. The results are expected to provide new ideas for the modern research on kidney injury-inducing Chinese medicine， offer new breakthrough points for the toxicity attenuation of Chinese medicine by compatibility and processing， and give insights into the future research of Chinese medicine toxicology on the basis of ensuring the safety and scientific application of Chinese medicine. MethodsThe animal， cell， and clinical studies of kidney injury-inducing Chinese medicine were retrieved from CNKI， Wanfang Data， VIP， PubMed， and Web of Science. The names and toxic components of renal injury-inducing Chinese medicine， renal injury sites， toxicity mechanisms， toxicity attenuation measures， and related evaluation methods were summarized. ResultsThe toxicity mechanisms of kidney injury-inducing Chinese medicine mainly involved oxidative stress， endoplasmic reticulum stress， inflammatory cell infiltration， and organic anion transporters. Processing and compatibility were the main toxicity attenuation measures. The evaluation methods encompassed animal experiments， cell models， network pharmacology， metabolomics， toxicology genomics， and fluorescent probe technology. ConclusionAt present， the toxicological verification of kidney injury-inducing Chinese medicine starts from toxic components and combines various experimental methods， which is more comprehensive and systematic than the previous studies based on only animal experiments. According to the classical theories of traditional Chinese medicine， the toxicity of kidney injury-inducing Chinese medicine is mainly attenuated by decocting in water， steaming， and frying. With the progress of science and technology， new processing methods for toxicity attenuation are emerging， and structural transformation， fermentation， and microwave methods are the key research directions of toxicity attenuation of Chinese medicine in recent years.
