Mechanism of action of tumor necrosis factor superfamily member 14 in chronic liver diseases

VernacularTitle:肿瘤坏死因子超家族因子14（LIGHT）在慢性肝病中的作用机制
Author: Yapeng MA ¹ ; Yanan MA ²
Author Information

1. Department of Business， Institute of Medical Device Testing Technology， Shanxi Provincial Inspection and Testing Center/Shanxi Institute of Standard Measurement Technology， Taiyuan 030000， China
2. Cancer Center， Shanxi Bethune Hospital， Shanxi Academy of Medical Sciences， Tongji Shanxi Hospital， The Third Hospital of Shanxi Medical University， Taiyuan 030000， China
Publication Type:Review
Keywords: Tumor Necrosis Factors; Liver Diseases; Signal Transduction
From: Journal of Clinical Hepatology 2025;41(4):778-783
CountryChina
Language:Chinese
Abstract: Tumor necrosis factor superfamily member 14 （TNFSF14） is a new member of the tumor necrosis factor superfamily member， and it mediates diverse biological functions through binding with herpes virus entry mediator， lymphotoxin-β receptor， and soluble decoy receptor 3， thereby exerting an important regulatory effect in inflammatory diseases， fibrotic diseases， and anti-tumor immunity. In recent years， the mechanism of LIGHT in the development and progression of liver diseases and its role in treatment have attracted more and more attention.