Research progress of traditional Chinese medicine regulating PI3K/Akt signaling pathway to promote chronic wound healing
- VernacularTitle:中药调控PI3K/Akt信号通路促进慢性创面愈合的研究进展
- Author:
Zhenhui ZHU
1
;
Zhi LI
2
;
Yu LENG
2
;
Tao CAI
1
;
Xuefa SHEN
1
;
Xianxue XIANG
1
;
Yongxin HUANG
1
Author Information
1. First Clinical Medical College，Guizhou University of Traditional Chinese Medicine，Guiyang 550002，China
2. Dept. of Anorectal Surgery，the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550001，China
- Publication Type:Journal Article
- Keywords:
TCM;
active ingredients;
couplet medicinals;
compound formulas;
chronic wound healing;
PI3K/Akt signaling
- From:
China Pharmacy
2025;36(8):1019-1024
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of chronic wound healing is complex. It is often difficult to heal due to a long course of disease， difficulty in treatment， and it seriously affects the quality of life in patients. The active ingredients， couplet medicinals， and compound formulas of traditional Chinese medicine （TCM） possess unique advantages in the treatment of chronic wound healing. The phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway is extremely critical in the treatment of chronic wound healing by regulating a series of biological processes， including cell apoptosis， angiogenesis， and inflammatory responses. This article reviews the relevant research on the regulation of the PI3K/Akt signaling pathway by TCM to promote chronic wound healing. It has been found that the active ingredients of TCM （such as geniposide， astragaloside， and ginsenosides， etc.）， and compound formulas （such as Chonghe ointment， Huanglian ointment， Shirun shaoshang ointment， etc.） mainly reduce inflammatory responses， promote angiogenesis， regulate cell autophagy， and accelerate wound healing by activating the PI3K/Akt signaling pathway； at the same time， there are also a few couplet medicinals（ such as Huangqi-Honghua） and compound formulas （such as Xiangpi Shengji ointment） that exert anti-inflammatory effects by inhibiting this signaling pathway， to promote wound healing.
