Efficacy of 3% diquafosol sodium ophthalmic solution in dry eye syndrome after cataract surgery and its impact on tear film stability
10.3980/j.issn.1672-5123.2025.5.29
- VernacularTitle:3%地夸磷索钠滴眼液治疗白内障术后干眼的效果及对泪膜稳定性的影响
- Author:
Xiuting LI
1
;
Yan QUAN
1
;
Lili WANG
1
Author Information
1. Department of Ophthalmology, Xi'an Aier Eye Hospital, Northwest University, Xi'an 710000, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
diquafosol sodium ophthalmic solution;
cataract surgery;
dry eye syndrome;
tear film stability
- From:
International Eye Science
2025;25(5):854-857
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the efficacy of 3% diquafosol sodium ophthalmic solution in treating dry eye syndrome following cataract surgery and its impact on tear film stability.METHODS: This prospective clinical study was conducted at Xi'an Aier Eye Hospital, Northwest University from January 2021 to January 2024. A total of 124 patients(124 eyes)who underwent cataract phacoemulsification were enrolled and randomly assigned to either the study group(62 cases, 62 eyes)or the control group(62 cases, 62 eyes)using a random number table. The study group received 3% diquafosol sodium ophthalmic solution four times daily for 1 mo, while the control group was treated with sodium hyaluronate eye drops four times daily for 1 mo. Clinical efficacy, tear film breakup time(BUT), Schirmer I test(SⅠt), corneal fluorescein staining(FL)score, inflammatory factors [interleukin-1β(IL-1β), interleukin-6(IL-6), and tumor necrosis factor-α(TNF-α)] levels in tears, and adverse reactions were compared between the two groups.RESULTS: After treatment, the effective rate was 93.5% in the study group and 87.1% in the control group, with no significant difference between the two groups(P>0.05). The study group showed significantly higher BUT, SⅠt values compared to the control group, while FL score, and inflammatory factor levels in tears were significantly lower at 1 mo after treatment(all P<0.05). The incidence of adverse reactions did not differ significantly between the two groups(P=0.198).CONCLUSION: The 3% diquafosol sodium ophthalmic solution significantly improves tear secretion and tear film stability in patients with dry eye syndrome after cataract surgery, effectively alleviating dry eye symptoms. It is a safe and effective treatment method.
