Detection status of thyroid nodules and its relationship with insulin resistance in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2025.02.012
- VernacularTitle:老年2型糖尿病患者并发甲状腺结节检出现状及其与胰岛素抵抗的关系研究
- Author:
Jia XIE
1
;
Siyang CHEN
2
;
Tong SUN
3
Author Information
1. General Practice Medical Center , West China Hospital , Sichuan University , Chengdu , Sichuan 610041, China
2. Health Management Center , General Practice Medical Center , West China Fourth Hospital , Sichuan University , Chengdu , Sichuan 610041, China
3. Department of Neurosurgery , West China Hospital,Sichuan University , Chengdu , Sichuan 610041, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Thyroid nodules;
Insulin resistance;
Association;
Evaluation value
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the status of thyroid nodules in elderly patients with type 2 diabetes mellitus (T2DM) and its relationship with insulin resistance. Methods A total of 324 elderly patients with T2DM admitted to West China Hospital of Sichuan University from January 2018 to December 2023 were selected as the study subjects. The detection status of thyroid nodules was analyzed. According to the presence of thyroid nodules, the patients were classified into thyroid nodule group and non-thyroid nodule group. The insulin resistance index (HOMA-IR) of the study subjects was measured. Spearman correlation analysis was applied to analyze the correlation between concurrent thyroid nodules and HOMA-IR. ROC curve was drawn to analyze the value of HOMA-IR in assessing the risk of thyroid nodules in elderly patients with T2DM. Results Among the 324 elderly T2DM patients, 211 cases of thyroid nodules were detected, with a detection rate of 65.12%. The detection ratio of thyroid nodules in males and females was 1:1.24. The thyroid nodule detection rate was different among patients with different levels of insulin resistance, and the detection rate of thyroid nodules in patients with HOMA-IR>2.0 was higher than that in patients with HOMA-IR≤2.0 (P<0.05). Correlation analysis indicated that HOMA-IR was positively correlated with thyroid nodule in elderly T2DM patients (r=0.650, P<0.05). ROC curve revealed that the area under the curve (AUC), sensitivity, and specificity of HOMA-IR in evaluating thyroid nodules were 0.911, 81.99%, and 96.46%, respectively. Conclusion The risk of thyroid nodules is high in elderly patients with T2DM, and the detection rate in women is higher than that in men, which is closely related to insulin resistance level. HOMA-IR values can provide a reference for the early evaluation of thyroid nodules in elderly T2DM patients.
