Dietary nutrition status and nutritional intervention strategy of 1302 patients with Alzheimer's disease
10.3969/j.issn.1006-2483.2025.02.011
- VernacularTitle:1302例阿尔茨海默病患者膳食营养现状及干预策略
- Author:
Yufang WANG
1
;
Yuanfang ZHAO
1
;
Xiaomei HAO
1
;
Yining LIANG
1
Author Information
1. Department of Neurology , Xijing Hospital , The First Affiliated Hospital of Air Force Military Medical University , Xi'an , Shaanxi 710032 , China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Dietary nutrition;
Nutritional intervention;
Cognitive function;
Quality of life
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the dietary nutrition status and nutritional intervention strategy of patients with Alzheimer’s disease (AD). Methods Among the 1 332 patients with AD diagnosed at Xijing Hospital from January 2021 to December 2023 were enrolled as the study subjects. The dietary intake data of patients were collected through questionnaire surveys and dietary reviews. During the study period, 30 patients did not complete the intervention due to withdrawal or loss of follow-up. Based on the actual number of people who completed the intervention, AD patients were randomly divided into intervention group (n=651, individualized nutritional intervention strategy) and control group (n=651, routine nutritional intervention), and both groups were intervened for 3 months. The cognitive function (MMSE score and MoCA score), nutritional status (MNA scale, NRS-2002 scale), and quality of life (GQOL-74) of the two groups of AD patients were compared to evaluate the effectiveness of the intervention strategies. Results A total of 1 332 questionnaires were distributed, and 1 302 valid questionnaires were finally recovered, with an effective recovery rate of 97.75% (1 302/1 332). The survey results showed that there were no statistical differences in baseline characteristics and dietary nutrition status between the two groups of AD patients before intervention (P>0.05). After nutritional intervention, the cognitive function, quality of life, and nutritional status of patients in the intervention group were significantly improved. The MMSE score, MoCA score, MNA score, and GQOL-74 score of the intervention group were significantly higher than those of the control group, while the NRS-2002 score was lower than that of the control group (P<0.05). Conclusion Nutritional intervention strategy has a significant effect on improving nutritional status, cognitive function, and quality of life of AD patients.
