Association between intestinal barrier disruption in liver failure and the cGAS-STING signaling pathway
- VernacularTitle:肝衰竭肠道屏障损伤与环鸟苷酸-腺苷酸合酶（cGAS）-干扰素基因刺激因子（STING）信号通路的关系
- Author:
Qiao TANG
1
;
Chao ZHOU
1
;
Ning ZHANG
1
;
Man GONG
1
Author Information
- Publication Type:Review
- Keywords: Liver Failure; Gastrointestinal Microbiome; Signaling Pathway
- From: Journal of Clinical Hepatology 2025;41(3):574-579
- CountryChina
- Language:Chinese
- Abstract: Liver failure is a common severe syndrome of liver diseases with high mortality. The function and structural integrity of the intestinal barrier as an entity are closely associated with the development and progression of liver failure. The cGAS-STING signaling pathway can participate in innate immune response by recognizing DNA produced by pathogen invasion and host cell damage and inducing the production of type I interferon. Numerous studies have shown that activation of the cGAS-STING pathway can significantly impact the cellular structure， mucosal components， and commensal bacteria of the intestinal barrier. This article reviews the interplay between the cGAS-STING signaling pathway and intestinal barrier disruption in liver failure， in order to provide novel insights for the clinical management of liver failure.
