Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure
- VernacularTitle:肠道菌群及其代谢物在慢加急性肝衰竭发生发展中的作用
- Author:
Ke SHI
1
;
Qun ZHANG
1
;
Xianbo WANG
1
;
Ying FENG
1
Author Information
- Publication Type:Review
- Keywords: Gastrointestinal Microbiome; Metabolism; Acute-On-Chronic Liver Failure
- From: Journal of Clinical Hepatology 2025;41(3):568-573
- CountryChina
- Language:Chinese
- Abstract: Acute-on-chronic liver failure （ACLF） is a dangerous disease with severe conditions， rapid progression， and high short-term mortality. Intestinal flora and metabolites are closely associated with the development， progression， and pathogenesis of ACLF. During the development of ACLF， the destruction of intestinal integrity and the dysregulation of intestinal microecology and its metabolites mediate immune disturbance and thus aggravate systemic inflammatory response. This article elaborates on the role of intestinal flora and metabolites in the development and progression of ACLF and related therapeutic strategies.
