Role of amino acid metabolism in autoimmune hepatitis and related therapeutic targets

VernacularTitle:氨基酸代谢在自身免疫性肝炎中的作用机制及相关治疗靶点
Author: Peipei GUO ¹ ; Yang XU ¹ ; Jiaqi SHI ² ; Yang WU ² ; Lixia LU ² ; Bin LI ² ; Xiaohui YU ¹
Author Information

1. Department of Gastroenterology， The Second Hospital of Lanzhou University， Lanzhou 730030， China
2. The First Clinical Medical College of Gansu University of Chinese Medicine， Lanzhou 730000， China
Publication Type:Review
Keywords: Hepatitis， Autoimmune; Amino Acids; Molecular Targeted Therapy
From: Journal of Clinical Hepatology 2025;41(3):547-551
CountryChina
Language:Chinese
Abstract: Autoimmune hepatitis （AIH） is a chronic inflammatory liver disease. The pathogenesis of AIH remains unclear， but it is mainly autoimmune injury caused by the breakdown of autoimmune tolerance due to the abnormal activation of the immune system， while the specific molecular mechanism remains unknown. Recent studies have shown that abnormal amino acid metabolism plays an important role in the development and progression of AIH. This article reviews the research advances in amino acid metabolic reprogramming in AIH， in order to provide a theoretical basis for amino acid metabolism as a new target for the clinical diagnosis and treatment of AIH.