Chemical consitituents and hypoglycemic activity of Qinhuai No. 1 Rehmannia glutinosa
10.16438/j.0513-4870.2024-0803
- VernacularTitle:覃怀1号鲜地黄化学成分及其降糖活性研究
- Author:
Meng YANG
1
;
Zhi-you HAO
1
;
Xiao-lan WANG
2
;
Chao-yuan XIAO
1
;
Jun-yang ZHANG
1
;
Shi-qi ZHOU
1
;
Xiao-ke ZHENG
1
;
Wei-sheng FENG
3
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou; The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou
3. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou; The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou; Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou
- Publication Type:Research Article
- Keywords:
italic>Rehmannia glutinosa;
neomartynoside A;
phenylethanol glycoside;
phenylpropanoid;
isolation and identification;
hypoglycemic activity
- From:
Acta Pharmaceutica Sinica
2025;60(1):205-210
- CountryChina
- Language:Chinese
-
Abstract:
Eight compounds were isolated and purified from the ethyl acetate part of 70% acetone extract of Rehmannia glutinosa by various chromatographic techniques such as silica gel, MCI gel CHP-20, ODS, Toyopearl HW-40C, combined with TLC and semi-preparative HPLC. Their structures were elucidated by modern spectroscopy techniques (NMR, MS, UV, IR), and identified as neomartynoside A (1), osmanthuside B6 (2), martynoside (3), isomartynoside (4), (E)-p-hydroxycinnamic acid (5), caffeic acid (6), ferulic acid (7), and methyl caffeate (8). Compound 1 is a new phenylethanol glycoside, which was identified as neomartynoside A. Compound 2 was isolated from Rehmannia glutinosa for the first time. In addition, compounds 2, 6 and 7 significantly increased relative glucose consumption, showing potential hypoglycemic activity.
