Four new sesquiterpenoids from the roots of <italic>Atractylodes macrocephala</italic>

VernacularTitle:白术根中4个新倍半萜类化合物
Author: Gang-gang ZHOU ¹ ; Jia-jia LIU ¹ ; Ji-qiong WANG ¹ ; Hui LIU ² ; Zhi-Hua LIAO ³ ; Guo-wei WANG ¹ ; Min CHEN ¹ ; Fan-cheng MENG ¹
Author Information

1. Southwest University College of Pharmaceutical Science, Chongqing
2. Foshan University School of Medicine, Foshan
3. School of Life Sciences, Southwest University, Chongqing
Publication Type:Research Article
Keywords: italic>Atractylodes macrocephala; chemical constituent; sesquiterpenoid; extraction and isolation; structural elucidation
From: Acta Pharmaceutica Sinica 2025;60(1):179-184
CountryChina
Language:Chinese
Abstract: The chemical constituents in dried roots of Atractylodes macrocephala were investigated in this study. Through utilizing normal-phase silica gel and ODS column chromatography, TLC, and semi-preparative HPLC, 4 new sesquiterpenoids were purified from the ethyl acetate extract of A. macrocephala. By various spectroscopic techniques, such as 1D and 2D NMR, HR-ESI-MS, IR, UV, and CD, their structures were identified as atractylmacron A (1), 9β-hydroxyasterolide (2), atractylenolide H (3), atractylenolide J (4). Compound 1 possesses a rare 6/7 bicyclic skeleton.