Progress in the study of anti-inflammatory active components with anti-inflammatory effects and mechanisms in Caragana Fabr.
10.16438/j.0513-4870.2024-0587
- VernacularTitle:锦鸡儿属植物抗炎活性成分与抗炎作用和机制研究进展
- Author:
Yu-mei MA
1
;
Ju-yuan LUO
2
;
Tao CHEN
2
;
Hong-mei LI
3
;
Cheng SHEN
2
;
Shuo WANG
2
;
Zhi-bo SONG
3
;
Yu-lin LI
2
Author Information
1. Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining; Qinghai Institute of Health Sciences, Xining; University of Chinese Academy of Sciences, Beijing
2. Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining
3. Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining; University of Chinese Academy of Sciences, Beijing
- Publication Type:Research Article
- Keywords:
italic>Caragana Fabr.;
active component;
anti-inflammatory effect and mechanism
- From:
Acta Pharmaceutica Sinica
2025;60(1):58-71
- CountryChina
- Language:Chinese
-
Abstract:
The plants of the genus Caragana Fabr. are desert plants of the Leguminosae family, which are widely used in traditional ethnomedicine, with the effects of nourishing Yin and nourishing blood, dispelling wind and removing dampness, clearing heat and detoxifying toxins. The anti-inflammatory effect of Caragana Fabr. has attracted much attention, the research on the related mechanism has made some progress, but it lacks systematic collation. By summarising the anti-inflammatory effects of the active ingredients of Caragana Fabr., the authors found that they have good anti-inflammatory activities on different inflammatory cell models in vitro, and have good improvement effects on rheumatoid arthritis, colitis, complex nephritis, and acute lung injury and other disease models. The anti-inflammatory effects of the active components of this genus mainly include the reduction of the levels of a variety of pro-inflammatory factors, and the signalling pathways involved mainly include TLR4/NF-κB, TLR4/MAPK, TLR4/NF-κB/IRF3, JAK/STAT-1, ERK/STAT-1 and so on. Therefore, the paper mainly reviews the research progress on the anti-inflammatory effects and mechanisms of the Caragana Fabr. plants and their active components according to disease types, with a view to providing reference for the in-depth study of their anti-inflammatory activities and the development of new products with related functions.
