HerbRNomes: ushering in the post-genome era of modernizing traditional Chinese medicine research
10.16438/j.0513-4870.2024-1029
- VernacularTitle:本草RNA组——开启中药现代化研究的后基因组时代
- Author:
Yu TIAN
1
;
Hai SHANG
1
;
Gui-bo SUN
1
;
Wei-dong ZHANG
2
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
HerbRNomes;
ncRNA;
self-regulation;
cross-species regulation;
ribonucleic acid drug
- From:
Acta Pharmaceutica Sinica
2025;60(2):300-313
- CountryChina
- Language:Chinese
-
Abstract:
With the completion of the "Human Genome Project" and the smooth progress of the "Herbal Genome Project", the research wave of RNAomics is gradually advancing, opening the research gateway for the modernization of traditional Chinese medicine (TCM) and initiating the post-genome era of medicinal plant RNA research. Therefore, this article proposes for the first time the concept of HerbRNomes, which involves constructing databases of medicinal plant, medicinal fungus, and medicinal animal RNA at different stages, from different origins, and in different organs. This research aims to explore the role of HerbRNA in self-genetic information transmission, functional regulation, as well as cross-species regulation functional mechanisms and key technologies. It also investigates application scenarios, providing a theoretical basis and research ideas for the resistance of TCM or medicinal plants to adversity and stress, molecular assistant breeding, and the development of small nucleic acid drugs. This article reviews recent research progress in elucidating the molecular mechanisms of the transmission and expression of genetic information, self-regulation and cross-species regulation of herbs at the RNA level, along with key technologies. It proposes a development strategy for small nucleic acid drugs based on HerbRNomes, providing theoretical support and guidance for the modernization of TCM based on HerbRNomes research.
