From Golgiphagy to Golgimedicine — a new strategy for disease prevention and treatment targeting the Golgi apparatus
10.16438/j.0513-4870.2024-0994
- VernacularTitle:从高尔基体自噬到高尔基体医学——以高尔基体为靶标的疾病防治新策略
- Author:
Cheng-xiao FU
1
;
Lin-xi CHEN
2
Author Information
1. Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 421001, China; Department of Pharmacy, the First Affiliated Hospital, University of South China, Hengyang 421001, China
2. Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 421001, China
- Publication Type:Research Article
- Keywords:
Golgi apparatus;
Golgiphagy;
Golgimedicine;
organelle;
isease prevention and treatment
- From:
Acta Pharmaceutica Sinica
2025;60(2):280-287
- CountryChina
- Language:Chinese
-
Abstract:
Functional disorders of the Golgi apparatus are harmful to the health of organisms, leading to various diseases. Removing damaged Golgi apparatus is crucial for maintaining cellular homeostasis, therefore, autophagy of Golgi apparatus has gradually attracted attention. This article summarizes Golgi autophagy, briefly describes its structure and functions, Golgi autophagy receptors, and the role of Golgi autophagy in disease treatment. It also proposes the new concept of Golgimedicine, which looks forward to the role of Golgi in disease diagnosis, treatment, prognosis, genetic diseases, and rare diseases. This article aims to explore the scientific connotations of Golgi autophagy, Golgi structure and function from the perspective of Golgimedicine, providing theoretical references for drug target research, new drug development, and the healthy development of humanity.
