Exploring the safety and the countermeasures of rational use of Psoraleae Fructus based on the evolution of efficacy/toxicity records in ancient and modern literature
10.16438/j.0513-4870.2024-0818
- VernacularTitle:从古今文献效/毒记载演变探讨补骨脂安全性与安全合理用药对策
- Author:
Ying-jie XU
1
;
Xiao-yan ZHAN
2
;
Zhao-fang BAI
2
;
Xiao-he XIAO
1
Author Information
1. China Military Institute of Chinese Medicine, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China; Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. China Military Institute of Chinese Medicine, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China; Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China
- Publication Type:Research Article
- Keywords:
Psoraleae Fructus;
security;
hepatotoxicity;
genetic mechanism;
safe and rational drug use countermeasure
- From:
Acta Pharmaceutica Sinica
2025;60(2):314-322
- CountryChina
- Language:Chinese
-
Abstract:
Psoraleae Fructus is derived from the dried fruit of the Psoralea corylifolia L. It has the effects of tonifying the kidney, strengthening the Yang, warming the spleen and stopping diarrhea, and is used for the treatment of kidney deficiency and impotence, lumbar soreness and cold pain, osteoporosis and other diseases, and it is a commonly used tonic traditional Chinese medicine in Chinese medicine clinics in China. However, in recent years, the clinical adverse reactions of Psoraleae Fructus (PF) and related preparations have been increasingly reported, especially hepatotoxicity, which has become a bottleneck in the clinical application of PF and associated preparations. The safety of PF was rarely recorded in ancient texts, but modern clinical and experimental research has shown that PF not only has direct toxicity but also has immune-idiosyncratic toxicity. For this reason, this study comprehensively analyzes the evolution of PF effect/toxicity records in ancient and modern canonical literature, and combines with the progress of modern pharmacology and toxicology research, to conduct an in-depth discussion on the clinical characteristics, causative mechanisms and risk factors of PF hepatotoxicity. On this basis, based on the three-dimensional "human-medicine-use" precise prevention and control strategy for the safety risk of traditional Chinese medicine proposed by the author's team, safety risk prevention and control measures for PF and related preparations were developed, aiming at guiding the safe and rational use of PF and related preparations in the clinic and promoting the healthy and sustainable development of PF-related industries.
