Progress on antisense oligonucleotide in the field of antibacterial therapy
10.16438/j.0513-4870.2024-0607
- VernacularTitle:反义核酸在抗菌治疗领域的研究进展
- Author:
Jia LI
1
;
Xiao-lu HAN
2
;
Shi-yu SONG
3
;
Jin-tao LIN
1
;
Zhi-qiang TANG
4
;
Zeng-ming WANG
1
;
Liang XU
1
;
Ai-ping ZHENG
1
Author Information
1. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
2. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China; Troops 32104 of People's Liberation Army of China, Alashanmeng 735400, China
3. Chongqing Medical University, Chongqing 400016, China
4. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China; College of Pharmacy, Yanbian University, Yanji 133002, China
- Publication Type:Research Article
- Keywords:
nucleic acid drug;
antisense oligonucleotide;
antibacterial;
rug delivery;
gene therapy
- From:
Acta Pharmaceutica Sinica
2025;60(2):337-347
- CountryChina
- Language:Chinese
-
Abstract:
With the widespread use of antibiotics, drug-resistant bacterial infections have become a significant threat to human health. Finding new antibacterial strategies that can effectively control drug-resistant bacterial infections has become an urgent task. Unlike small molecule drugs that target bacterial proteins, antisense oligonucleotide (ASO) can target genes related to bacterial resistance, pathogenesis, growth, reproduction and biofilm formation. By regulating the expression of these genes, ASO can inhibit or kill bacteria, providing a novel approach for the development of antibacterial drugs. To overcome the challenge of delivering antisense oligonucleotide into bacterial cells, various drug delivery systems have been applied in this field, including cell-penetrating peptides, lipid nanoparticles and inorganic nanoparticles, which have injected new momentum into the development of antisense oligonucleotide in the antibacterial realm. This review summarizes the current development of small nucleic acid drugs, the antibacterial mechanisms, targets, sequences and delivery vectors of antisense oligonucleotide, providing a reference for the research and development of antisense oligonucleotide in the treatment of bacterial infections.
