Chemical consitituents and hypoglycemic activity of Sophora tonkinensis
10.16438/j.0513-4870.2024-0549
- VernacularTitle:山豆根化学成分及降糖活性研究
- Author:
Xiao-yun YAN
1
;
Ling-feng QIN
2
;
Rui ZHANG
2
;
Ya-nan YANG
2
;
Jin-ying TIAN
2
;
Fei YE
2
;
Xu ZHANG
2
;
Pei-cheng ZHANG
2
;
Guo-cheng WANG
3
Author Information
1. College of Pharmacy, Inner Mongolia Medical University, Hohhot; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
3. College of Pharmacy, Inner Mongolia Medical University, Hohhot
- Publication Type:Research Article
- Keywords:
italic>Sophora tonkinensis;
chemical constituent;
chromone;
benzofuran;
italic>α-glucosidase inhibition;
protein tyrosine phosphatase-1B inhibition
- From:
Acta Pharmaceutica Sinica
2024;59(11):3135-3140
- CountryChina
- Language:Chinese
-
Abstract:
Eleven compounds were isolated from the ethyl acetate fraction of the 95% aqueous ethanol extract of the roots of Sophora tonkinensis by silica gel, ODS, Sephadex LH-20 column chromatography, and semi-preparative RP-HPLC. Their structures were identified as 7-hydroxy-8-isopentenylchromone (1), furo[2,3-f]-1,3-benzodioxole-7-carboxylic acid (2), 6-[3-(2′,4′-dihydroxyphenyl)acryloyl]-7-hydroxy-2,2-dimethyl-8-(3-methyl-2-butenyl)-2H-benzopyran (3), flemichapparin B (4), tectorigenin (5), genistein (6), 6-hydroxy-1,3-benzodioxole-5-carboxylic acid (7), vanillic acid (8), protocatechuic acid (9), 2,4-dihydroxybenzoic acid (10), and p-hydroxybenzoic acid (11) through extensive spectroscopic data (IR, UV, HR-ESI-MS, and NMR spectra). Among them, compounds 1 and 2 were new compounds. In addition, compound 3 showed significant α-glucosidase and protein tyrosine phosphatase-1B (PTP1B) inhibitory activities with IC50 values of 5.595 and 0.320 μmol·L-1, respectively.
