A new model for screening active ingredients in traditional Chinese medicine based on the interactions between gut microorganisms and G protein-coupled receptor
10.16438/j.0513-4870.2024-0333
- VernacularTitle:基于肠道微生物与G蛋白偶联受体互作关系探讨中药有效成分筛选新模式
- Author:
Chang-min LIU
1
;
Yi-xuan ZHENG
1
;
Jing-sheng YU
2
;
Hui WANG
1
;
Shi-lin CHEN
1
;
Chi SONG
1
Author Information
1. Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu
2. Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing
- Publication Type:Research Article
- Keywords:
gut microbiome;
G protein-coupled receptor;
isease;
traditional Chinese medicine;
rug screening
- From:
Acta Pharmaceutica Sinica
2024;59(11):3042-3056
- CountryChina
- Language:Chinese
-
Abstract:
Gut microbiome and their metabolites are closely related to human diseases, which influence the development of diseases by interacting with receptors. G protein-coupled receptor (GPCR) is a receptor superfamily that exists on the surface of cell membrane, which is involved in a wide range of human physiological activities. GPCR is currently considered as important drug targets. Traditional Chinese medicines (TCM) are characterized by multi-components, multi-targets, and multi-pathways. More and more studies have demonstrated that TCM can ultimately intervene in diseases by modulating gut microbiome and their metabolites, affecting their interactions with GPCR. This review discusses the status of gut microbiome and human diseases, the interactions of gut microbiome and their metabolites with GPCR, and the status of GPCR drug development. Based on the above contents, a new model of "TCM-gut microbiome panel-GPCR-disease" is proposed. The interactions between active ingredients of TCM, gut microbiome panel, and GPCR and their effects on disease are elucidated through multi-omics techniques. This review will provide new ideas for analyzing the pharmacological mechanism of TCM efficacy and searching for new targets of TCM.
