Research progress in drug carriers across the blood-brain barrier

Wan-xin CAO; Yi-hui YANG; Hong YANG; Sen ZHANG; Yi-zhi ZHANG; Fang XU; Wan LI; Yue HAO; Xiao-xue LI; Xu ZHANG; Guan-hua DU; Jin-hua WANG

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Research progress in drug carriers across the blood-brain barrier

VernacularTitle:跨血脑屏障药物载体的研究进展
Author: Wan-xin CAO ¹ ; Yi-hui YANG ¹ ; Hong YANG ¹ ; Sen ZHANG ¹ ; Yi-zhi ZHANG ¹ ; Fang XU ¹ ; Wan LI ¹ ; Yue HAO ¹ ; Xiao-xue LI ² ; Xu ZHANG ¹ ; Guan-hua DU ¹ ; Jin-hua WANG ¹
Author Information

1. Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
2. Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Shenyang Pharmaceutical University, Shenyang
Publication Type:Research Article
Keywords: rug carrier; blood-brain barrier; intracerebral fate; liposome; exosome; apoptotic body; cell-penetrating peptide; cell-targeting peptide
From: Acta Pharmaceutica Sinica 2024;59(12):3222-3231
CountryChina
Language:Chinese
Abstract: The blood-brain barrier (BBB) plays a crucial role in maintaining the homeostasis of the brain's internal environment, which poses challenges to the treatment of central nervous system diseases. Drug carriers can aid in the delivery of therapeutic agents across the BBB to exert their pharmacological effects. The article reviewed the pathways for drug delivery across the BBB, the intracerebral fate and the classification of drug carriers and focuses on the functions and characteristics of liposomes, exosomes, apoptotic bodies, cell-penetrating peptides, and cell-targeting peptides. The review will provide an outlook on the future and challenge of research in the field of drug delivery across the BBB.