Study on secondary metabolites of an endophytic fungi Alternaria tenuissima Pas85
10.16438/j.0513-4870.2024-0575
- VernacularTitle:一株内生真菌Alternaria tenuissima Pas85次生代谢产物研究
- Author:
Ya-ling JIANG
1
;
Wei-ping LI
2
;
Cheng-cheng HU
3
;
Xue-ru GUO
3
;
Yang WANG
3
;
Xin-xin ZHANG
3
;
Ke LI
4
;
Wen-yuan LI
1
Author Information
1. Henan Engineering Research Center of Water Environment and Health, Zhengzhou University of Industrial Technology, Zhengzhou; School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology, Zhengzhou
2. Henan Engineering Research Center of Water Environment and Health, Zhengzhou University of Industrial Technology, Zhengzhou; Zhengzhou Ecological Environment Bureau Xinzheng Branch, Zhengzhou
3. School of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology, Zhengzhou
4. Henan Engineering Research Center of Water Environment and Health, Zhengzhou University of Industrial Technology, Zhengzhou
- Publication Type:Research Article
- Keywords:
italic>Phragmites australis;
endophytic fungus;
italic>Alternaria tenuissima;
secondary metabolite;
anti methicillin-resistant Staphylococcus aureus
- From:
Acta Pharmaceutica Sinica
2024;59(12):3330-3334
- CountryChina
- Language:Chinese
-
Abstract:
A new alkaloid (1) and six known compounds (2-7) were isolated from the solid fermentation extract of the endophytic fungus Alternaria tenuissima Pas85 of Phragmites australis by silica gel column chromatography, Sephadex LH-20 column chromatography, high performance liquid chromatography and other chromatographic techniques. The structures of these compounds were determined by HREIMS, NMR, IR spectroscopy, and literature comparison, and the anti MRSA (methicillin-resistant Staphylococcus aureus) activity of 1-5 were tested. Compounds 1, 2, 3 and 4 exhibited certain inhibitory activity with MIC values of 64, 4, 32 and 32 μg·mL-1, respectively, and compound 5 showed no significant inhibitory activity.
