A new pregnane steroid from Poria cocos
10.16438/j.0513-4870.2024-0466
- VernacularTitle:茯苓中一个新孕甾烷类化合物
- Author:
Chao-yuan XIAO
1
;
Zhi-you HAO
1
;
Meng YANG
1
;
Shi-qi ZHOU
1
;
Jun-yang ZHANG
1
;
Xiao-ke ZHENG
1
;
Yan-jun SUN
2
;
Wei-sheng FENG
2
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou; The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou; The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou; Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou
- Publication Type:Research Article
- Keywords:
italic>Poria cocos;
chemical constituent;
pregnane steroid;
tetracyclic triterpenoid;
structural identification
- From:
Acta Pharmaceutica Sinica
2024;59(12):3325-3329
- CountryChina
- Language:Chinese
-
Abstract:
The 95% ethanol extract of Poria cocos was separated and purified by ODS, MCI gel CHP20 and silica gel column chromatography combined with the semi-preparative HPLC. The chemical structures of the isolated compounds were identified by NMR, MS, IR, and calculated NMR methods. Seven compounds were isolated from Poria cocos and identified as 20S-2β,3α,15α,19,20-hydroxy-pregnane-7-ene (1), dehydroeburicoic acid monoacetate (2), eburicoic acid acetate (3), dehydroeburicoic acid (4), eburicoic acid (5), dehydropachymic acid (6), pachymic acid (7). Compound 1 is a new pregnane steroid.
