Research progress on the characteristic clinical manifestations of pathologic myopia and their related genes
10.3980/j.issn.1672-5123.2025.4.18
- VernacularTitle:病理性近视特征性临床表现及其相关基因研究进展
- Author:
Jing KONG
1
;
Ying WEN
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
pathologic myopia;
clinical manifestations;
genes
- From:
International Eye Science
2025;25(4):620-626
- CountryChina
- Language:Chinese
-
Abstract:
Pathologic myopia is a leading cause of visual impairment worldwide. Its characteristic clinical manifestations include posterior staphyloma caused by pathological elongation of the axial length, myopic maculopathy and high myopia-associated optic neuropathy. Extensive research conducted both domestically and internationally has consistently demonstrated that genetics plays a significant role in the occurrence and progression of pathologic myopia. With the innovative development of genetics, it has become possible to predict, prevent, control, and treat pathologic myopia at the gene level. This paper reviews the characteristic clinical manifestations of pathologic myopia and its related genes to provide a basis for the etiology of pathologic myopia and potential targets for therapeutic intervention, to provide a reference for treating pathologic myopia and its complications at the genetic level, and to explore new and effective ways to control the development of pathologic myopia.
