Research status and prospect of prevention and treatment of radiation-induced lung injury
10.13491/j.issn.1004-714X.2025.01.022
- VernacularTitle:放射性肺损伤防治研究现状与展望
- Author:
Bo ZHENG
1
;
Guirong DING
1
Author Information
1. Department of Radiation Medical Protection, School of Military Preventive Medicine, Fourth Military Medical University, Shaanxi Province, Xi'an 710032 China;Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shaanxi Province, Xi'an 710032 China.
- Publication Type:ReviewArticles
- Keywords:
Radiation-induced lung injury;
Pathogenesis;
Prevention and treatment;
Mesenchymal stem cell
- From:
Chinese Journal of Radiological Health
2025;34(1):135-141
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is a primary modality for thoracic malignant tumor treatment; however, it can also induce damage to normal lung tissue. The pathogenesis of radiation-induced lung injury remains unclear and is believed to be primarily associated with DNA damage and inflammatory responses. The existing drugs for the prevention and treatment of radiation-induced lung injury are limited by issues such as modest efficacy, short half-life, and serious adverse reactions. It is urgent to find new effective prevention and treatment methods. Recently, stem cell-based therapies and traditional Chinese medicine have emerged as promising treatment strategies, offering new hope for patients with radiation-induced lung injury. This review outlines the fundamental aspects of radiation-induced lung injury and discusses potential strategies for its prevention and treatment.
