Research progress on the pathogenesis of vitamin D in autism spectrum disorder
10.16835/j.cnki.1000-9817.2025054
- VernacularTitle:维生素D在孤独症谱系障碍发病机制中的作用研究进展
- Author:
LIU Zizi, JIN Yu
1
Author Information
1. Department of Maternal and Child Health/Research Center of Child and Adolescent Psychological and Behavioral Development, School of Public Health, Sun Yatsen University, Guangzhou (510080) , Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Autistic disorder;
Research;
Child
- From:
Chinese Journal of School Health
2025;46(2):300-304
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:In order to explore the pathogenesis of autism spectrum disorder (ASD) from a new perspective, it is found through literature review that vitamin D(Vit D) may play a significant role in the onset and development of ASD by inhibiting early brain overgrowth, regulating metabolism of central nervous system, modulating immune responses, reducing inflammation and influencing genome stability. Furthermore, Vit D supplementation in individuals with ASD has shown to alleviate symptoms. However, the mechanisms by which Vit D affects ASD remains unclear, and the effectiveness of Vit D treatment in improving ASD symptoms remains controversial due to variations in sample sizes, detection methods, dosage and confounding factors. Future research needs to focus on multi center, large scale randomized controlled trials and ASD animal models with Vit D deficiency to further explore the specific role of Vit D in the pathogenesis and treatment of ASD, which could provide reliable evidence for the early detection, intervention and treatment of ASD.
- Full text:2025031908252574532刘姿镃.pdf
