Efficacy Evaluation of Initial Double Filtration Plasmapheresis in NMOSD with Respiratory Insufficiency
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0118
- VernacularTitle:双重膜滤过式血浆置换治疗伴呼吸衰竭的视神经脊髓炎谱系疾病的疗效评价
- Author:
Sai ZHANG
1
;
Xi CHEN
1
;
Tao ZENG
2
Author Information
1. Guangzhou First People′s Hospital， Guangzhou 510180， China
2. Zhujiang Hospital of Southern Medical University， Guangzhou 510280， China
- Publication Type:Journal Article
- Keywords:
neuromyelitis optica spectrum disorder;
respiratory insufficiency;
double filtration plasmapheresis;
medulla oblongata;
upper spinal cord
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(1):154-160
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo discuss the clinical manifestations and image features of Neuromyelitis Optica Spectrum Disorder （NMOSD）with respiratory insufficiency. We present a retrospective review about the use of double filtration plasmapheresis in the treatment of the acute attack of NMOSD in these patients. MethodsAll of our patients with central respiratory insufficiency who suffered attacks of NMOSD were retrospectively considered for inclusion. Extended Disability Status Scale（EDSS）scores were compared within six months after double membrane filtration plasma exchange. ResultsThe clinical data of the six patients included were analyzed. Magnetic Resonance Imaging confirmed that the demyelinating plaques in our patients could involve the medulla oblongata and upper spinal cord. They were managed by plasma exchange given as an initial therapy. The clinical symptoms improved significantly and the patients were successfully withdrawn from the ventilator，with EDSS scores significantly reduced （P<0.001）. ConclusionDemyelination of medulla oblongata and upper spinal cord in NMOSD may lead to acute life-threatening respiratory compromise， and early initiation of double filtration plasmapheresis can be a safe and effective treatment.
