Research Progress of Stem Cells Transplantation in Treatment of Cognitive Impairment After Stroke

VernacularTitle:干细胞移植治疗卒中后认知障碍的相关研究进展
Author: Rui PAN ¹ ; Ming ZHANG ²
Author Information

1. School of Rehabilitation，Henan University of Traditional Chinese Medicine，Zhengzhou 450046，China
2. The First Affiliated Hospital of Henan University of Traditional Chinese Medicine，Zhengzhou 450000，China
Publication Type:Review
Keywords: stem cells transplantation; stroke; cognitive dysfunction; mesenchymal stem cells; neural stem cells
From: Journal of Sun Yat-sen University(Medical Sciences) 2025;46(1):41-49
CountryChina
Language:Chinese
Abstract: Stroke is a common acute cerebrovascular disease. Post-stroke cognitive impairment （PSCI） is one of the most common complications of stroke， which seriously affects the quality of life and physical health of patients. As a cutting-edge medical therapy， stem cells transplantation has great potential in the treatment of PSCI by reducing inflammation， promoting axon regeneration and immune regulation， and has become the focus of current research. However， the relationship between stem cells transplantation and PSCI has not been systematically summarized. Therefore， this paper will briefly summarize the biological functions of different types of stem cells， systematically comb out and summarize the mechanisms of stem cells transplantation in PSCI regulation and its applications in PSCI treatment， providing a deeper understanding and strategy for clinical PSCI management.