Research Progress in Single-cell Sequencing for Ischemia-reperfusion Injury
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0101
- VernacularTitle:单细胞测序在缺血再灌注领域的研究进展
- Author:
Jie ZHANG
1
;
Zhengfei YANG
1
Author Information
1. Department of Emergency，Sun Yat-sen Memorial Hospital of Sun Yat-sen University， Guangzhou 510120，China
- Publication Type:Review
- Keywords:
ischemia reperfusion injury;
single cell sequencing;
apoptosis;
transplantation;
heterogeneity;
signal pathway
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(1):1-10
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia reperfusion injury （IRI） is often accompanied by serious clinical manifestations， including myocardial hibernation， acute heart failure， brain dysfunction， kidney dysfunction， gastrointestinal dysfunction， liver transplant rejection， systemic inflammatory response syndrome， multiple organ dysfunction syndrome， and so on， which pose important treatment challenges for doctors in clinical practice. Single cell sequencing technology is high-throughput sequencing of the genome， transcriptome， or epigenome at the single-cell level， in order to reveal cellular heterogeneity， and to understand the developmental trajectory， type， state， and various interactions of cells. Since its first discovery， single-cell sequencing technology has been widely applied in various fields， especially in early diagnosis and personalized treatment of tumors. This article mainly reviews the application and progress of single-cell sequencing in various organ dysfunctions caused by IRI， so as to further understand the mechanisms and signaling pathways of IRI， and to provide new ideas for targeted therapy of organ IRI.
