Application of Anti-tumor Compatibility Structure of Chinese Medicine
10.13422/j.cnki.syfjx.20242027
- VernacularTitle:中药抗肿瘤配伍结构应用探析
- Author:
Lanpin CHEN
1
;
Feng TAN
1
;
Xiaoman WEI
2
;
Junyi WANG
3
;
Liu LI
2
;
Mianhua WU
2
;
Haibo CHENG
2
;
Dongdong SUN
1
Author Information
1. School of Clinical Medicine of Nanjing University of Chinese Medicine， Nanjing 210023， China
2. The First School of Clinical Medicine of Nanjing University of Chinese Medicine， Nanjing 210023， China
3. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine for Tumor Prevention and Treatment，Nanjing 210023，China
- Publication Type:Journal Article
- Keywords:
anti-tumor;
compatibility of Chinese medicine;
herb pair;
tri-herbal combination;
state-targeted treatment based on syndrome differentiation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):198-208
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors are one of the major diseases that endanger human life and health. Chinese medicine has unique advantages in clinical anti-tumor treatment. However， how to translate the anti-tumor effects of Chinese medicine into clinical practice is the core issue that must be addressed in the process of treating malignant tumors with traditional Chinese medicine （TCM）. Unlike modern chemical drugs， the compatibility application of Chinese medicine is the key factor that determines whether Chinese medicine can achieve optimal anti-tumor efficacy and realize the goal of "enhancing efficacy and reducing toxicity". The formulation structure based on this compatibility is the basic form for the safe， efficient， and rational clinical use of anti-tumor Chinese medicine， and it mainly includes three categories： herb pairs， tri-herbal combinations， and compound compatibility. Although herb pairs have the characteristics of a simple structure and strong targeting （enhancing efficacy and reducing toxicity）， they often have a single effect and cannot fully address the complex pathogenesis of tumors. As a result， herb pairs are rarely used alone in practice. Compared to herb pairs， tri-herbal combinations broaden the application scope of herbs in clinical treatment， but their therapeutic range remains limited. The traditional "sovereign， minister， assistant， and guide" compound prescription， which includes herb pairs and tri-herbal combinations， improves the efficacy of herbs in treating serious diseases， hypochondriasis， chronic diseases， and miscellaneous disorders. However， due to the limitations of its historical background， it has not been integrated with modern clinical practice and modern pharmacological research， which restricts the development of compound compatibility theory. With the emergence of modern medical technology， it has been combined with traditional compatibility theory of Chinese medicine to create an innovative modern compatibility theory. This includes the "aid medicine" theory derived from modern Chinese medicine pharmacology， which compensates for the inability of the "sovereign， minister， assistant， and guide" theory to accurately apply medicine. Additionally， the "state-targeted treatment based on syndrome differentiation" theory， developed from pharmacology and modern medicine， addresses the deficiency in disease cognition in the "sovereign， minister， assistant， and guide" theory. Under the guidance of these compatibility forms and theories， clinical anti-tumor Chinese medicine can exert its maximum anti-tumor efficacy， which is of great significance for the application of Chinese medicine in clinical tumor treatment.
