Clinical study on serum indirect bilirubin and carotid intima-media thickness in acute cerebral infarction
10.3969/j.issn.1673-9701.2024.23.014
- VernacularTitle:急性脑梗死患者血清间接胆红素与颈动脉内膜中层厚度的临床研究
- Author:
Xiao WANG
1
;
Chunhua LEI
;
Yunfei ZHU
;
Suqin GUO
Author Information
1. 无锡市第二中医医院康复医学科,江苏无锡 2141211
- Keywords:
Acute cerebral infarction;
Serum indirect bilirubin;
Carotid intima-media thickness;
Correlation analysis
- From:
China Modern Doctor
2024;62(23):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum indirect bilirubin(IBIL)levels and carotid intima-media thickness(CIMT)of acute cerebral infarction patients.Methods A total of 229 patients with acute cerebral infarction at Wuxi No.2 Chinese Medicine Hospital from July 2021 to November 2023 were divided into the intima-media thickness group(CIMT≥0.9mm,n=108)and intima-media normal group(CIMT<0.9mm,n=121)according to CIMT values.The differences in gender,age,body mass index,smoking history,history of alcohol drinking,hypertension,coronary heart disease,diabetes,hyperlipidemia,total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),total cholesterol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,triglyceride,fasting blood glucose,uric acid,and cystatin C were compared between the two groups.To further elucidate the association between serum bilirubin levels and CIMT using both univariate and multivariate analysis.Results The two groups showed significant differences in gender,body mass index and IBIL in the results(P<0.05).However,there was no significant difference in age,history of alcohol drinking,smoking history,diabetes,coronary heart disease,hypertension,hyperlipidemia,TBIL,DBIL,total cholesterol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,triglyceride,fasting blood glucose,uric acid and cystatin C levels(P>0.05).Binary Logistic regression analysis indicated that gender,body mass index and IBIL were significant independent predictors of CIMT values(P<0.05).Conclusion Serum indirect bilirubin level is inversely associated with CIMT in acute cerebral infarction patients,which may be one of the protective factors of atherosclerosis.
