Study on the correlation between plasma ammonia and 25-hydroxyvitamin D levels in SeLECTS
10.3969/j.issn.1673-9701.2024.17.015
- VernacularTitle:伴中央颞区棘波的儿童自限性癫痫发作与血浆氨及25羟维生素D水平相关性研究
- Author:
Ting XU
1
;
Qiuying WANG
;
Shihua LIU
;
Chao ZHANG
;
Ping ZHONG
;
Li CAO
Author Information
1. 安徽医科大学附属宿州医院神经内科,安徽宿州 234000
- Keywords:
Self-limited epilepsy in children with spines in the central temporal region;
Plasma ammonia;
25-hydroxyvitamin D
- From:
China Modern Doctor
2024;62(17):62-65,75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between clinical characteristics of self-limited epilepsy in children with spines in the central temporal region(SeLECTS)and plasma levels of ammonia,25-hydroxyvitamin D[25(OH)D].Methods A total of 90 SeLECTS children admitted to Suzhou Hospital Affiliated to Anhui Medical University from September 2021 to October 2023 were selected as the case group,and 90 healthy children were included in the control group during the same period.The differences in plasma ammonia and serum 25(OH)D levels between the two groups were compared.The correlation between clinical characteristics of SeLECTS and plasma levels of ammonia,25(OH)D was retrospectively analyzed.Results Plasma ammonia concentration in case group was significantly higher than that in control group(P＜0.05).The level of 25(OH)D was significantly lower than that of control group(P＜0.05).There were statistically significant differences in plasma ammonia concentration among patients with different age,duration and frequency of SeLECTS(P＜0.05).There were statistically significant differences in serum 25(OH)D content among children with different age,frequency and season of SeLECTS(P＜0.05).The correlation between onset time,onset age and onset frequency was significant at 0.01 level.The correlation between plasma ammonia concentration and age of onset,time of onset and frequency of onset was significant at 0.05 level.At the same time,the correlation between 25(OH)D content and seizure time,seizure frequency and plasma ammonia concentration was significant at 0.05 level.The age of onset,frequency and duration of attacks were positively correlated with plasma ammonia levels of SeLECTS.Age of onset was positively correlated with 25(OH)D level,and frequency of onset was negatively correlated with 25(OH)D level.Conclusion SeLECTS attacks are significantly correlated with plasma ammonia and serum 25(OH)D levels,and both elevated plasma ammonia levels and decreased 25(OH)D levels increase the risk of SeLECTS attacks.Therefore,detection of plasma ammonia and serum 25(OH)D levels in children can provide evidence for prevention,disease assessment,diagnosis and treatment of SeLECTS.
