Effects of infection on circulating tumor cells and tumor markers levels in patients after radical gastrectomy
10.3760/cma.j.cn115355-20240423-00199
- VernacularTitle:胃癌根治术后感染对患者循环肿瘤细胞及肿瘤标志物水平的影响
- Author:
Jiazhi WEN
1
;
Rong XIANG
Author Information
1. 西安市长安医院普通外科，西安 710018
- Keywords:
Gastric neoplasms;
Postoperative infection;
Circulating tumor cells;
Tumor markers;
Gastric function
- From:
Cancer Research and Clinic
2024;36(11):847-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of infection on circulating tumor cells (CTC) and tumor markers levels in patients after radical gastrectomy.Methods:A retrospective case series study was conducted. A total of 100 patients who underwent radical gastrectomy admitted to Chang'an Hospital in Xi'an from January 2020 to December 2023 were selected. The patients were divided into the infection group and the non-infection group according to whether the patients were infected or not after surgery. The general clinical data, CTC positive rate on the third day after surgery and peripheral blood tumor markers levels between the 2 groups were compared.Results:Among 100 gastric cancer patients who underwent radical gastrectomy, 21 cases (21%) developed postoperative infection, mainly including respiratory infection (38.10%, 8/21) and surgical site infection (23.8%, 5/21). The infection group experienced longer surgery durations [(3.4±1.0) h vs. (3.0±0.4) h] and more intraoperative blood loss [(415±93) ml vs. (370±75) ml] compared to the non-infection group, and the differences were statistically significant (all P < 0.05). The positive rate of CTC, white blood cells, neutrophil-to-lymphocyte ratio, carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199), and carcinoembryonic antigen (CEA) levels in the infection group were higher than those in the non-infection group on the third day after surgery, and the differences were significantly significant (all P < 0.05). Levels of gastrin and motilin in the infection group were lower than those in the non-infection group on the third day after surgery, and the differences were statistically significant (all P < 0.05). Conclusions:Postoperative infection of gastric cancer causes an increase in CTC positive rate, peripheral blood CA135, CA199, CEA levels in patients after radical gastrectomy, which affects the patients' recovery of gastrointestinal function.
