Progress of RAS gene mutation in thyroid cancer
10.3760/cma.j.cn115355-20230915-00107
- VernacularTitle:RAS基因突变在甲状腺癌中的研究进展
- Author:
Xuyang ZHOU
1
;
Xinyu WANG
;
Wenxiao SONG
;
Yafei SHI
Author Information
1. 济宁医学院临床医学院，济宁 272000
- Keywords:
Thyroid neoplasms;
Genes, ras;
Mutation;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2024;36(9):713-716
- CountryChina
- Language:Chinese
-
Abstract:
In recent 20 years, the incidence of thyroid cancer has shown an obvious upward trend, especially in female patients. As the second most common molecular marker of thyroid cancer, RAS mutation affects the occurrence and development of thyroid cancer mainly through RAS-RAF-MEK-ERK and PI3K-Akt signaling pathways. However, the effect of RAS mutation on the invasive characteristics, prognosis and survival rate of thyroid cancer is still controversial. This article reviews the research progress of RAS gene mutation in thyroid cancer.
