Progress of RNA N6-methyladenosine modification in tumor immune evasion
10.3760/cma.j.cn115355-20240125-00052
- VernacularTitle:RNA N6甲基腺嘌呤修饰在肿瘤免疫逃逸中的研究进展
- Author:
Jiahe YANG
1
;
Yeyang DAI
;
Cheng CHEN
;
Xiaoyuan CHU
Author Information
1. 南京大学医学院附属金陵医院肿瘤科，南京 210002
- Keywords:
Neoplasms;
Immunity;
N6-methyladenosine modification;
Tumor escape
- From:
Cancer Research and Clinic
2024;36(9):709-712
- CountryChina
- Language:Chinese
-
Abstract:
Tumor immunity permeates the entire process of tumorigenesis and development, and influences the prognosis of patients. Immunosuppressive tumor microenvironment and reduced immunogenicity of tumor cells can help tumor cells escape from T cell attack, leading to immune evasion. N6-methyladenosine, one of the most common modifications of eukaryotic messenger RNA, has been reported to regulate tumorigenesis, metastasis and drug resistance. Recent studies revealed that N6-methyladenosine plays an important role in tumor immune evasion. This article summarizes the role and molecular mechanisms of N6-methyladenosine modification in tumor immune evasion in immune cells and tumor cells, and discusses the potential value and challenges of targeting N6-methyladenosine regulatory molecules in combination with immunotherapy to improve anti-tumor efficacy, in order to provide new ideas for tumor immunotherapy.
