Role of ubiquitin-specific peptidase in the development and progression of hepatocellular carcinoma
10.3760/cma.j.cn115355-20230804-00038
- VernacularTitle:泛素特异性肽酶在肝癌发生、发展中的作用
- Author:
Xiuyun CHEN
1
;
Bin XIAO
;
Zhaohui SUN
Author Information
1. 南方医科大学附属广东省人民医院（广东省医学科学院）医学研究中心，广州 510080
- Keywords:
Carcinoma, hepatocellular;
Ubiquitin-specific peptidase;
Ubiquitination
- From:
Cancer Research and Clinic
2024;36(5):392-395
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-specific protease (USP) is a major member of the deubiquitinating enzymes (DUB) family. Dysregulation of DUB could lead to dysfunction of the ubiquitin system, which in turn regulates the tumor progression. USP regulates the development and progression of hepatocellular carcinoma (HCC) by selectively degrading or stabilizing substrate proteins related to oncogenes, tumor suppressors, DNA damage repair, and cell cycle. This article summarizes the research progress of USP in HCC and the application of USP-specific small molecule inhibitors, providing a reference for targeting USP as a diagnostic and therapeutic tool for HCC.
