Research progress of cyclic guanosine monophosphate in inherited retinal degeneration
10.3760/cma.j.cn511434-20240701-00246
- VernacularTitle:环磷酸鸟苷在遗传性视网膜变性中的研究进展
- Author:
Zishi LIU
1
;
Tong LI
;
Xiaodong SUN
Author Information
1. 上海交通大学附属第一人民医院眼科 国家眼部疾病临床医学研究中心 上海市眼底病重点实验室上海眼视觉与光医学工程技术研究中心, 上海 200080
- Keywords:
Inherited retinal degeneration;
Cyclic guanosine monophosphate;
Phototransduction;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(11):898-904
- CountryChina
- Language:Chinese
-
Abstract:
Inherited retinal degeneration (IRD) is a group of fundus diseases characterized by a high degree of genetic heterogeneity and clinical heterogeneity, and more than 300 genetic mutations have been identified in association with IRD. Dysregulation of the intracellular second messenger cyclic guanosine monophosphate (cGMP) plays an important role in the development of IRD. cGMP participates in phototransduction process in photoreceptors. Abnormally elevated cGMP over-activate protein kinase G and cyclic nucleotide-gated channel, causing protein phosphorylation and Ca 2+ overload, respectively, and these two cGMP-dependent pathways may individually or collectively drive photoreceptor degenerative lesions and death; therefore, reducing cGMP synthesis and blocking downstream signaling can be considered as treatment strategies. Investigating the molecular mechanisms of cGMP dysregulation in photoreceptor degeneration may provide a more comprehensive picture of the pathogenesis of IRD, as well as ideas for finding new therapeutic targets and designing therapeutic programs.
