Research progress of mast cells in non-allergic fundus diseases
10.3760/cma.j.cn511434-20240417-00157
- VernacularTitle:肥大细胞在非过敏性眼底疾病中的研究进展
- Author:
Jinyi LONG
1
;
Da LONG
Author Information
1. 上海交通大学医学院附属第六人民医院眼科, 上海 200233
- Keywords:
Mast cells;
Fundus diseases;
Non-allergic;
Ophthalmic diseases;
Therapeutic strategies;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(9):733-737
- CountryChina
- Language:Chinese
-
Abstract:
Mast cell (MC) play a crucial role in non-allergic fundus diseases, including uveitis, diabetic retinopathy, and age-related macular degeneration. MCs can profoundly influence the pathological processes of these diseases by regulating inflammatory responses, promoting angiogenesis, and facilitating tissue remodeling through the degranulation and release of mediators such as histamine, cytokines, and enzymes. The application of MC-associated inhibitors has been shown to effectively mitigate or inhibit the progression of these pathologies, offering a promising strategy for treating ocular diseases. Understanding the current state of MC research in fundus diseases will enhance our insight into their role in the pathophysiological mechanisms of these conditions and encourage further research aimed at providing more effective treatment options for patients.
