The progress of the study of lipid globules in the retina and choroid
10.3760/cma.j.cn511434-20230911-00380
- VernacularTitle:视网膜及脉络膜中脂质小球的研究进展
- Author:
Pingping LI
1
;
Lu LI
;
Jianhua WU
Author Information
1. 武汉大学附属爱尔眼科医院, 武汉 430000
- Keywords:
Lipid globules;
Age-related macular degeneration;
Retina;
Choroidal;
Tomography, optical coherence;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(4):324-328
- CountryChina
- Language:Chinese
-
Abstract:
Lipid globules in retina and choroid are new definitions based on pathology and high-resolution optical coherence tomography (OCT). OCT examination shows that the lipid globules are low reflective circular cavities in the choroid and retina, without strong reflective boundaries around them, followed by a characteristic superreflective tail. It occurs in healthy human eyes and in age-related macular degeneration characterized by retinal pigment epithelium (RPE) atrophy. Its characteristic superreflective tail is the key to distinguishing it from other diseases. At present, the understanding of lipid globules is still in the initial stage. Although lipid globules can be observed in healthy human eyes, a certain prevalence rate indicates that they are associated with choroidal hypoperfusion and RPE atrophy. In the future, larger randomized controlled trials and longer follow-up time are needed to explore its pathogenesis, pathological characteristics and treatment prognosis.
