Research progress in the role of LRRC15 in the pathogenesis of non-tumor diseases

VernacularTitle:LRRC15在非肿瘤疾病发病机制中的研究进展
Author: Miaomiao XIN ¹ ; Xin GUAN ; Qingrui YANG ; Min FU
Author Information

1. 山东第一医科大学附属省立医院风湿免疫科，济南　250021
Keywords: Leucine-rich repeat containing 15(LRRC15); Infection; Rheumatoid arthritis; Osteoarthritis; Osteogenesis
From: Chinese Journal of Microbiology and Immunology 2024;44(8):734-740
CountryChina
Language:Chinese
Abstract: Leucine-rich repeat containing protein 15 (LRRC15) gene encodes a type Ⅰ transmembrane protein with 15 leucine-rich repeats(LRRs), which is involved in the occurrence and development of various diseases. Previous studies on LRRC15 gene have mostly focused on its tumor-promoting effects, while the immunoregulatory roles of this gene in non-neoplastic diseases are in the exploratory stage, such as controlling viral infection, participating in changing the functions of osteoblasts and chondrocytes, and promoting the release of pro-inflammatory cytokines, osteogenic differentiation, as well as the proliferation, migration and angiogenesis of fibroblast-like synoviocytes. This paper summarizes the research status and possible roles of LRRC15 gene in non-tumor diseases, hoping to reveal the significant role of this gene in immune regulation.