Pathogenesis and treatment progress of chronic kidney disease-associated pruritus

VernacularTitle:慢性肾脏病相关性瘙痒的发病机制及治疗进展
Author: Mingming PAN ¹ ; Bicheng LIU
Author Information

1. 东南大学附属中大医院肾脏科，南京　210009
Keywords: Renal dialysis; Pruritus; Uremia; Pathogenesis; Treatment
From: Chinese Journal of Nephrology 2024;40(10):846-850
CountryChina
Language:Chinese
Abstract: Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in patients with end-stage renal disease, which strongly reduces the quality of life. The pathogenesis of CKD-aP is complex, with unclear etiology, and there is no recognized treatment method. This paper reviews the research progress of the pathogenesis of CKD-aP, including the hypotheses of toxin deposition, peripheral neuropathy, immune and inflammatory system disorder, and opioid receptor imbalance, and the treatment of CKD-aP, including adequate dialysis, local skin medication, systemic medication, nutrition, ultraviolet B, and acupuncture.