Tocilizumab and rituximab in the treatment of multicenter Castleman's disease with steroid-resistant nephrotic syndrome: a case report
10.3760/cma.j.cn441217-20240322-00334
- VernacularTitle:托珠单抗联合利妥昔单抗治疗多中心型Castleman病合并激素耐药肾病综合征1例
- Author:
Huayan ZHU
1
;
Xin LEI
;
Liangliang CHEN
;
Jianghua CHEN
;
Fei HAN
Author Information
1. 浙江大学医学院附属第一医院肾脏病中心，浙江大学肾脏病研究所，杭州 310003，湖州 313000
- Keywords:
Castleman disease;
Nephrotic syndrome;
Rituximab;
Tocilizumab
- From:
Chinese Journal of Nephrology
2024;40(9):749-752
- CountryChina
- Language:Chinese
-
Abstract:
The paper reports a rare case of idiopathic multicentric Castleman's disease with nephrotic syndrome as the first presentation. The patient was a 68-year-old male, presented with edema at admission. His clinical manifestations included nephrotic syndrome, and multiple enlarged lymph nodes. Renal biopsy showed minimal change disease, and cervical lymph node biopsy showed Castleman's disease. The patient received treatment of glucocorticoid combined with tocilizumab, and then rituximab. After 14 months of follow-up, the patient achieved remission of nephrotic syndrome.
