Adynamic bone disease complicated with uraemic tumoral calcinosis: two cases and literature review

VernacularTitle:无动力性骨病合并尿毒症瘤样钙质沉着症2例及文献复习
Author: Na CHEN ¹ ; Tian XU ; Hong LIU ; Na TIAN ; Xiaoliang ZHANG
Author Information

1. 东南大学附属中大医院肾内科　东南大学肾脏病研究所，南京　210009
Keywords: Teriparatide; Uremia; Parathyroid hormone; Calcinosis; Adynamic bone disease; Tumoral calcinosis
From: Chinese Journal of Nephrology 2024;40(9):741-745
CountryChina
Language:Chinese
Abstract: Adynamic bone disease (ABD) is a common type of chronic kidney disease-mineral and bone disorder (CKD-MBD). It is characterized by decreased bone transport and bone remodeling. Clinically, low parathyroid hormone (PTH) is an important feature of ABD. Tumoral calcinosis (TC) is a rare benign lesion characterized by extensive calcification of soft tissue and periarticular structures, but its exact pathogenesis is still unclear. Although the incidence of uremic tumoral calcinosis (UTC) in dialysis patients is low, it has a serious adverse impact on the quality of life and prognosis of patients. This paper reports two patients with ABD complicated with UTC. One patient had TC involving both hands, both feet, both scapulae, sternoclavicular joint, ilium, femoral head and sacrococcygeal region, and the other patient had TC involving the left shoulder. After treatment with recombinant human PTH teriparatide injection, sodium thiosulfate, phosphorus reduction, and full dialysis, the patients' condition improved.