Diagnosis and treatment of recurrent peritonitis associated with peritoneal dialysis caused by Salmonella identified through metagenomic next-generation sequencing: a case report and literature review

VernacularTitle:宏基因二代测序协助沙门菌致复发性腹膜透析相关性腹膜炎诊治1例及文献复习
Author: Zhe ZHANG ¹ ; Xiaofen LIU ; Chao XIE ; Yaozhong KONG ; Peiyi YE
Author Information

1. 佛山市第一人民医院肾内科，佛山528000
Keywords: Salmonella; Peritoneal dialysis; Peritonitis; Metagenome; Next-generation sequencing
From: Chinese Journal of Nephrology 2024;40(6):487-490
CountryChina
Language:Chinese
Abstract: This paper reports a case of recurrent peritoneal dialysis-associated peritonitis caused by Salmonella, as identified through metagenomic next-generation sequencing. This patient was treated regularly with peritoneal dialysis due to stage 5 chronic kidney disease. One month ago, she was hospitalized for peritoneal dialysis-associated peritonitis. The result of bacterial culture of the dialysate was Salmonella, and she was discharged after anti-infective treatment for 3 weeks. However, on the 12th day after discharge, the patient was readmitted to the hospital due to peritonitis.Both metagenomic next-generation sequencing and bacterial culture of the fluid confirmed the presence of Salmonella. After 3 weeks of intraperitoneal and intravenous anti-infection treatment, the patient underwent metagenomic next-generation sequencing to assess pathogen eradication before discharge.