Exploration of pathogenesis and treatment of epilepsy based on astrocyte energy metabolism
10.3760/cma.j.cn115354-20240804-00452
- VernacularTitle:基于星形胶质细胞能量代谢探究癫痫的发病与治疗
- Author:
Zihao ZHANG
1
;
Yiming LI
;
Weitao WANG
;
Daopei ZHANG
;
Huailiang ZHANG
Author Information
1. 河南中医药大学第一附属医院脑病科/中西医防治重大疾病河南省协同创新中心，郑州 450000
- Keywords:
Epilepsy;
Astrocyte;
Lipid accumulation;
Lactic acid;
Adenosine;
Ketone
- From:
Chinese Journal of Neuromedicine
2024;23(10):1069-1073
- CountryChina
- Language:Chinese
-
Abstract:
Astrocytes play a key role in maintaining the homeostasis and function of the central nervous system. Abnormal lipid accumulation, ferroptosis, elevated lactic acid, and high DNA methylation mediated by astrocytes in their own or toxic states are particularly closely related to seizures. In recent years, epilepsy treatment from astrocyte energy metabolism perspective has become a research hotspot. Metabolic therapy, such as ketogenic diet, can inhibit seizures via a variety of mechanisms as astrocyte homeostasis maintenance. This paper reviews the relationship between astrocyte energy metabolism and epilepsy pathogenesis and its related metabolic therapy, in order to provide new ideas for clinical treatment of drug-resistant epilepsy.
