Recent advance in papillary craniopharyngioma: from molecular biological characteristics to comprehensive treatment strategies
10.3760/cma.j.cn115354-20240802-00449
- VernacularTitle:从分子生物学特征到综合治疗策略：乳头型颅咽管瘤的研究进展
- Author:
Ning LUO
1
;
Yi LIN
;
Tao HONG
;
Zhixiong LIN
Author Information
1. 首都医科大学三博脑科医院神经外科，北京 100093
- Keywords:
Papillary craniopharyngioma;
Molecular biology;
Comprehensive treatment strategy;
Targeted therapy
- From:
Chinese Journal of Neuromedicine
2024;23(10):1055-1063
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, molecular biological research on papillary craniopharyngioma (PCP) has made significant breakthrough, leading to the clinical application of targeted therapy, which has yielded encouraging outcome. This article reviews the molecular biological characteristics of PCP, with a particular focus on mechanism of BRAF V600E gene mutation and its role in tumorigenesis. Furthermore, it also summarizes PCP comprehensive treatment strategies combining targeted therapy, surgery, and radiation therapy and proposes future research directions for precision PCP management, aiming at providing some references for clinical colleagues.
