Recent advance in mechanism of low-intensity transcranial ultrasound stimulation in cognitive disorders
10.3760/cma.j.cn115354-20240711-00406
- VernacularTitle:低强度经颅超声刺激治疗认知障碍性疾病的机制研究进展
- Author:
Yan ZHOU
1
;
Chengdong YUAN
;
Yi ZHANG
Author Information
1. 遵义医科大学第二附属医院麻醉科，遵义 563000
- Keywords:
Low-intensity transcranial ultrasound stimulation;
Cognitive impairment;
Neuroplasticity;
Mechanism study
- From:
Chinese Journal of Neuromedicine
2024;23(8):831-836
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive disorders refer to diseases that affect an individual's thinking, memory, learning, and understanding abilities. Common cognitive disorders include Alzheimer's disease, vascular cognitive impairment, Parkinson's disease, and epilepsy. The pathogenesis of these diseases may involve neuroplasticity (especially synaptic plasticity, neurotransmitters changes, and neurotrophic factor levels), neuroinflammation, cerebral hemodynamics, and brain electrical rhythms; however, treatments have not yet made significant breakthroughs. Low-intensity transcranial ultrasound stimulation (LITUS) is an emerging non-invasive therapeutic approach that improves cognitive function by stimulating specific brain regions with low-intensity ultrasound waves, thereby regulating neuronal activity. While LITUS has shown promising efficacy in treating cognitive disorders, its underlying mechanisms remain unclear. This paper focuses on the relation of LITUS with synaptic plasticity, neurotransmitter release, neurotrophic factor regulation, neuroinflammatory response, cerebral hemodynamic regulation, and cerebral electrical rhythm regulation, aiming to provide new ideas for treatment of cognitive disorders.
