Recent advance in influence of orthostatic hypotension in cognitive dysfunction in patients with multiple system atrophy

VernacularTitle:体位性低血压对多系统萎缩患者认知功能障碍的影响研究进展
Author: Xin WANG ¹ ; Jia KANG ; Jing PAN
Author Information

1. 内蒙古医科大学第二附属医院神经内科，呼和浩特　010020
Keywords: Multiple system atrophy; Orthostatic hypotension; Cognitive dysfunction
From: Chinese Journal of Neuromedicine 2024;23(4):409-412
CountryChina
Language:Chinese
Abstract: Orthostatic hypotension (OH) is the most prominent autonomic neurodysfunction in patients with multiple system atrophy (MSA). Dementia and cognitive fluctuations at early course of the disease remain the exclusion criteria for MSA, however, increased studies have indicated that mild cognitive impairment is prevalent in MSA. OH is associated with an increased risk of cognitive dysfunction in patients with Parkinson's disease (PD) due to recurrent cerebral hypoperfusion, and earlier, more prevalent and more severe OH occurs in MSA patients than that in PD patients; therefore, could OH serve as a modifier to improve cognitive dysfunction in MSA patients? Do the two interact as both cause and effect, or do they share a common neurobiological basis? This paper reviews the influence of OH in cognitive dysfunction in MSA patients, and summarizes the existing problems and looks forward to future research directions, with a view to enhance clinicians' understanding of OH and cognitive dysfunction in MSA patients.